Mnk1 May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MNK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of human Ortholog: 1p33
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  intracellular signal transduction; peptidyl-serine phosphorylation; protein phosphorylation; regulation of translation
Reference #:  Q9BUB5 (UniProtKB)
Alt. Names/Synonyms: MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK interacting serine/threonine kinase 1; MAPK signal-integrating kinase 1; MKNK1; MNK1
Gene Symbols: MKNK1
Molecular weight: 51,342 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Mnk1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein