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Mnk1
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MNK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation |
| Chromosomal Location of human Ortholog: 1p33 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; metal ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
intracellular signal transduction; peptidyl-serine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of translation
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Reference #:
Q9BUB5
(UniProtKB)
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Alt. Names/Synonyms: MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK interacting serine/threonine kinase 1; MAPK signal-integrating kinase 1; MKNK1; MNK1
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Gene Symbols: MKNK1
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Molecular weight:
51,342 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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Growth And Differentiation Control by MAPKs
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Phospholipase Signaling
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Regulation of P38 MAPKs
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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