PHC2 Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component:  heterochromatin; nucleoplasm; nucleus; PcG protein complex; PRC1 complex
Molecular Function:  DNA binding; identical protein binding; protein binding; zinc ion binding
Biological Process:  multicellular organism development; spermatogenesis
Reference #:  Q8IXK0 (UniProtKB)
Alt. Names/Synonyms: early development regulator 2 (homolog of polyhomeotic 2); early development regulator 2-like; Early development regulatory protein 2; EDR2; hPH2; MGC163502; PH2; PHC2; polyhomeotic 2; polyhomeotic homolog 2 (Drosophila); polyhomeotic-like 2; Polyhomeotic-like protein 2
Gene Symbols: PHC2
Molecular weight: 90,713 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein