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DDX29
ATP-binding RNA helicase involved in translation initiation. Required for efficient initiation on mammalian mRNAs with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Belongs to the DEAD box helicase family. DEAH subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.13; Helicase; Translation |
| Chromosomal Location of Human Ortholog: 5q11.2 |
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Cellular Component:
eukaryotic 43S preinitiation complex
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Molecular Function:
ATP binding; ribosomal small subunit binding; translation initiation factor activity
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Biological Process:
positive regulation of translational initiation; translational initiation
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Reference #:
Q7Z478
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent RNA helicase DHX29; DDX29; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29; DEAH (Asp-Glu-Ala-His) box polypeptide 29; DEAH box protein 29; DHX29; FLJ21492; Nucleic acid helicase DDXx
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Gene Symbols: DHX29
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Molecular weight:
155,236 Da
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Basal Isoelectric point:
8.3
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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