UBR1 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 15q15.2
Cellular Component:  cytoplasm; cytosol; proteasome complex; ubiquitin ligase complex
Molecular Function:  leucine binding; protein binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  cellular response to leucine; negative regulation of TOR signaling; protein ubiquitination; ubiquitin-dependent protein catabolic process via the N-end rule pathway
Disease: Johanson-blizzard Syndrome
Reference #:  Q8IWV7 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase UBR1; E3a ligase; JBS; MGC142065; MGC142067; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; ubiquitin ligase E3 alpha-I; ubiquitin protein ligase E3 component n-recognin 1; ubiquitin-protein ligase E3-alpha; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; UBR1
Gene Symbols: UBR1
Molecular weight: 200,211 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB