PALB2 Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of human Ortholog: 16p12.2
Cellular Component:  DNA repair complex; nuclear speck; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  DNA binding; protein binding
Biological Process:  animal organ morphogenesis; apoptotic process; double-strand break repair via homologous recombination; embryonic organ development; inner cell mass cell proliferation; mesoderm development; multicellular organism growth; negative regulation of apoptotic process; post-anal tail morphogenesis; somitogenesis
Disease: Breast-ovarian Cancer, Familial, Susceptibility To, 5; Fanconi Anemia, Complementation Group N; Pancreatic Cancer, Susceptibility To, 3
Reference #:  Q86YC2 (UniProtKB)
Alt. Names/Synonyms: DKFZp667I166; DKFZp686E1054; FANCN; FLJ21816; mutant partner and localizer of BRCA2; PALB2; Partner and localizer of BRCA2; PNCA3; truncated partner and localizer of BRCA2
Gene Symbols: PALB2
Molecular weight: 131,295 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein