SMARCA3 an enzyme with both helicase and E3 ubiquitin ligase activities. Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.1.-; EC 3.6.4.-; EC 6.3.2.-; EC; Helicase; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3q24
Cellular Component:  cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATPase activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; helicase activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  chromatin organization; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of transcription, DNA-templated
Reference #:  Q14527 (UniProtKB)
Alt. Names/Synonyms: DNA-binding protein/plasminogen activator inhibitor 1 regulator; DNA-binding protein/plasminogen activator inhibitor-1 regulator; helicase like transcription factor; Helicase-like transcription factor; HIP116; HIP116A; HLTF; HLTF1; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; RNF80; RUSH; SMARCA3; SNF2-like 3; SNF2L3; Sucrose nonfermenting protein 2-like 3; sucrose nonfermenting-like 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; ZBU1
Gene Symbols: HLTF
Molecular weight: 113,929 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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