SMARCA3
an enzyme with both helicase and E3 ubiquitin ligase activities. Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; EC 3.6.1.-; EC 3.6.4.-; EC 6.3.2.-; EC 6.3.2.19; Helicase; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of human Ortholog: 3q24 |
Cellular Component:
cytoplasm; nuclear matrix; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
ATP binding; ATP-dependent activity, acting on DNA; ATP-dependent chromatin remodeler activity; DNA binding; helicase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; zinc ion binding
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Biological Process:
chromatin remodeling; DNA repair; mRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of neurogenesis
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Reference #:
Q14527
(UniProtKB)
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Alt. Names/Synonyms: DNA-binding protein/plasminogen activator inhibitor 1 regulator; DNA-binding protein/plasminogen activator inhibitor-1 regulator; helicase like transcription factor; Helicase-like transcription factor; HIP116; HIP116A; HLTF; HLTF1; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; RNF80; RUSH; SMARCA3; SNF2-like 3; SNF2L3; Sucrose nonfermenting protein 2-like 3; sucrose nonfermenting-like 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; ZBU1
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Gene Symbols: HLTF
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Molecular weight:
113,929 Da
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Basal Isoelectric point:
8.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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