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FILIP1
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. Belongs to the FILIP1 family. Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 6q14.1 |
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Cellular Component:
actin cytoskeleton; cytosol; glutamatergic synapse; nucleolus; plasma membrane
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Biological Process:
modification of postsynaptic structure
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Disease: Neuromuscular Disorder, Congenital, With Dysmorphic Facies
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Reference #:
Q7Z7B0
(UniProtKB)
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Alt. Names/Synonyms: filamin A interacting protein 1; Filamin-A-interacting protein 1; FILIP; FILIP1; FLIP1; KIAA1275
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Gene Symbols: FILIP1
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Molecular weight:
138,109 Da
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Basal Isoelectric point:
8.46
Predict pI for various phosphorylation states
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| Select Structure to View Below |
FILIP1
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