PATL1 RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). Belongs to the PAT1 family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Isomerase; RNA-binding
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component:  cytoplasmic ribonucleoprotein granule; cytosol; nuclear speck; P-body; PML body
Molecular Function:  poly(G) binding; poly(U) RNA binding; protein binding; RNA binding
Biological Process:  cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Reference #:  Q86TB9 (UniProtKB)
Alt. Names/Synonyms: FLJ36874; hPat1b; MGC125671; MGC125672; PAT1 homolog 1, processing body mRNA decay factor; PAT1-like protein 1; Pat1b; PATL1; protein associated with topoisomerase II homolog 1; protein associated with topoisomerase II homolog 1 (yeast); Protein PAT1 homolog 1; Protein PAT1 homolog b
Gene Symbols: PATL1
Molecular weight: 86,850 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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