RBBP6 E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component:  chromosome; cytosol; nuclear speck; nucleolus; protein-containing complex
Molecular Function:  protein binding; protein kinase binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  cellular response to DNA damage stimulus; DNA replication; embryonic organ development; in utero embryonic development; mRNA processing; multicellular organism growth; protein polyubiquitination; regulation of DNA replication; somite development; ubiquitin-dependent protein catabolic process
Reference #:  Q7Z6E9 (UniProtKB)
Alt. Names/Synonyms: DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; P2PR; p53-associated cellular protein of testis; PACT; Proliferation potential-related protein; Protein P2P-R; RB-binding Q-protein 1; RBBP6; RBQ-1; RBQ1; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; Retinoblastoma-binding Q protein 1; SNAMA
Gene Symbols: RBBP6
Molecular weight: 201,564 Da
Basal Isoelectric point: 9.65  Predict pI for various phosphorylation states
Select Structure to View Below

RBBP6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein