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RBBP6
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 16p12.1 |
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Cellular Component:
centrosome; chromosome; cytosol; nuclear speck; nucleolus; nucleus; protein-containing complex
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Molecular Function:
protein binding; protein kinase binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
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Biological Process:
DNA damage response; DNA replication; embryonic organ development; in utero embryonic development; mRNA processing; multicellular organism growth; protein ubiquitination; regulation of DNA replication; somite development; ubiquitin-dependent protein catabolic process
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Reference #:
Q7Z6E9
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; P2PR; p53-associated cellular protein of testis; PACT; Proliferation potential-related protein; Protein P2P-R; RB binding protein 6, ubiquitin ligase; RB-binding Q-protein 1; RBBP6; RBQ-1; RBQ1; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; Retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA
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Gene Symbols: RBBP6
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Molecular weight:
201,564 Da
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Basal Isoelectric point:
9.65
Predict pI for various phosphorylation states
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