MKK3 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. A deletion and two point mutants found in colon cancer cell lines. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm
Molecular Function:  ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; cardiac muscle contraction; inflammatory response; p38MAPK cascade; peptidyl-tyrosine phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of protein kinase activity; positive regulation of transcription, DNA-templated; regulation of cytokine biosynthetic process; regulation of mitotic cell cycle; signal transduction
Reference #:  P46734 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen-activated protein kinase kinase 3; MKK3; MP2K3; PRKMK3
Gene Symbols: MAP2K3
Molecular weight: 39,318 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MKK3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein