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MKK3
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.12.2; Kinase, protein; MEK1 subfamily; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family |
| Chromosomal Location of human Ortholog: 17p11.2 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm
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Molecular Function:
ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
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Biological Process:
cardiac muscle contraction; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular response to vascular endothelial growth factor stimulus; cellular senescence; heart development; inflammatory response; MAPK cascade; negative regulation of hippo signaling; p38MAPK cascade; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein kinase activity; protein phosphorylation; regulation of cytokine production; response to ischemia; signal transduction; stress-activated protein kinase signaling cascade
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Reference #:
P46734
(UniProtKB)
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Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen-activated protein kinase kinase 3; MKK3; MP2K3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; SKK2; Stress-activated protein kinase kinase 2
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Gene Symbols: MAP2K3
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Molecular weight:
39,318 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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IL6 Signaling
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Regulation of P38 MAPKs
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TGF-ß Signaling
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Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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