Met Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis. (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Met family; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of human Ortholog: 7q31.2
Cellular Component:  basal plasma membrane; extracellular region; integral component of membrane; plasma membrane
Molecular Function:  ATP binding; identical protein binding; protein binding; protein phosphatase binding; protein tyrosine kinase activity
Biological Process:  branching morphogenesis of an epithelial tube; cell surface receptor signaling pathway; endothelial cell morphogenesis; entry of bacterium into host cell; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; MAPK cascade; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; semaphorin-plexin signaling pathway; signal transduction
Disease: Deafness, Autosomal Recessive 97; Hepatocellular Carcinoma; Osteofibrous Dysplasia, Susceptibility To; Renal Cell Carcinoma, Papillary, 1
Reference #:  P08581 (UniProtKB)
Alt. Names/Synonyms: AUTS9; c-Met; DFNB97; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; MET; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Gene Symbols: MET
Molecular weight: 155,541 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Met

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