WNT3 Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge. Required for normal embryonic development, and especially for limb development. Belongs to the Wnt family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 17q21.31-q21.32
Cellular Component:  endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; Golgi lumen; plasma membrane; Wnt signalosome
Molecular Function:  cytokine activity; frizzled binding; protein binding; protein domain specific binding; receptor ligand activity
Biological Process:  anterior/posterior axis specification; axon guidance; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in stem cell proliferation; cell fate commitment; cell morphogenesis; cellular response to retinoic acid; dorsal/ventral axis specification; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; gamete generation; gene expression; head morphogenesis; limb bud formation; mammary gland epithelium development; mesoderm formation; negative regulation of axon extension involved in axon guidance; neuron differentiation; positive regulation of collateral sprouting in absence of injury; positive regulation of gene expression; positive regulation of Wnt signaling pathway; regulation of neurogenesis; Spemann organizer formation at the anterior end of the primitive streak; stem cell proliferation
Disease: Tetraamelia, Autosomal Recessive
Reference #:  P56703 (UniProtKB)
Alt. Names/Synonyms: INT4; MGC131950; MGC138321; MGC138323; Proto-oncogene Int-4 homolog; Proto-oncogene Wnt-3; TETAMS; wingless-type MMTV integration site family, member 3; Wnt family member 3; WNT-3 proto-oncogene protein; WNT3
Gene Symbols: WNT3
Molecular weight: 39,645 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene