UCK2 Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.1.48; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of human Ortholog: 1q24.1

Cellular Component: cytoplasm; cytosol

Molecular Function: ATP binding; cytidine kinase activity; identical protein binding; uridine kinase activity

Biological Process: CMP biosynthetic process; CTP salvage; phosphorylation; UMP salvage

Reference #: Q9BZX2 (UniProtKB)

Alt. Names/Synonyms: Cytidine monophosphokinase 2; Testis-specific protein TSA903; TSA903; UCK 2; UCK2; UK; UMPK; uridine kinase; uridine monophosphate kinase; Uridine monophosphokinase 2; Uridine-cytidine kinase 2

Gene Symbols: UCK2

Molecular weight: 29,299 Da

Basal Isoelectric point: 6.24 Predict pI for various phosphorylation states

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UCK2

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