SLC22A2 Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of human Ortholog: 6q25.3

Cellular Component: apical plasma membrane; basal plasma membrane; basolateral plasma membrane; membrane; plasma membrane; presynapse

Molecular Function: acetylcholine transmembrane transporter activity; amine transmembrane transporter activity; choline transmembrane transporter activity; efflux transmembrane transporter activity; L-amino acid transmembrane transporter activity; L-arginine transmembrane transporter activity; monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; organic anion transmembrane transporter activity; organic cation transmembrane transporter activity; prostaglandin transmembrane transporter activity; putrescine transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; spermidine transmembrane transporter activity; thiamine transmembrane transporter activity; toxin transmembrane transporter activity; xenobiotic transmembrane transporter activity

Biological Process: acetylcholine transport; activation of cysteine-type endopeptidase activity involved in apoptotic process; amine transport; amino acid import across plasma membrane; body fluid secretion; choline transport; dopamine transport; dopamine uptake; epinephrine transport; export across plasma membrane; histamine transport; histamine uptake; L-alpha-amino acid transmembrane transport; L-arginine import across plasma membrane; L-arginine transmembrane transport; monoatomic cation transport; neurotransmitter transport; norepinephrine transport; norepinephrine uptake; organic cation transport; positive regulation of gene expression; prostaglandin transport; purine-containing compound transmembrane transport; putrescine transport; serotonin transport; serotonin uptake; spermidine transmembrane transport; spermidine transport; thiamine transmembrane transport; toxin transport; transport across blood-brain barrier; xenobiotic transport; xenobiotic transport across blood-brain barrier

Reference #: O15244 (UniProtKB)

Alt. Names/Synonyms: hOCT2; MGC32628; OCT2; organic cation transporter (OCT2); Organic cation transporter 2; S22A2; SLC22A2; solute carrier family 22 (organic cation transporter), member 2; Solute carrier family 22 member 2

Gene Symbols: SLC22A2

Molecular weight: 62,581 Da

Basal Isoelectric point: 8.68 Predict pI for various phosphorylation states

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SLC22A2

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