EDC4 In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). Belongs to the WD repeat EDC4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; nucleoplasm; nucleus; P-body
Molecular Function:  protein binding
Biological Process:  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Reference #:  Q6P2E9 (UniProtKB)
Alt. Names/Synonyms: Autoantigen Ge-1; Autoantigen RCD-8; EDC4; enhancer of mRNA decapping 4; Enhancer of mRNA-decapping protein 4; Ge-1; HEDLS; Human enhancer of decapping large subunit; RCD-8
Gene Symbols: EDC4
Molecular weight: 151,661 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EDC4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene