MAD1L1 Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. Belongs to the MAD1 family. Expressed weakly at G0/G1 and highly at late S and G2/M phase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component:  centrosome; condensed chromosome kinetochore; cytosol; kinetochore; mitotic spindle; nuclear pore nuclear basket; spindle
Molecular Function:  identical protein binding; kinetochore binding; protein binding
Biological Process:  cell division; mitotic cell cycle checkpoint; mitotic spindle assembly checkpoint; negative regulation of T cell proliferation; regulation of metaphase plate congression; thymus development
Disease: Prostate Cancer
Reference #:  Q9Y6D9 (UniProtKB)
Alt. Names/Synonyms: hMAD1; HsMAD1; MAD1; MAD1 mitotic arrest deficient like 1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1-like protein 1; MAD1L1; MD1L1; mitotic arrest deficient 1 like 1; Mitotic arrest deficient 1-like protein 1; Mitotic checkpoint MAD1 protein homolog; Mitotic spindle assembly checkpoint protein MAD1; mitotic-arrest deficient 1, yeast, homolog-like 1; PIG9; Tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181
Gene Symbols: MAD1L1
Molecular weight: 83,067 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below

MAD1L1

Protein Structure Not Found.


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