MAD1L1
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. Belongs to the MAD1 family. Expressed weakly at G0/G1 and highly at late S and G2/M phase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Cytoskeletal |
Chromosomal Location of human Ortholog: 7p22.3 |
Cellular Component:
centrosome; cytosol; kinetochore; MAD1 complex; mitotic spindle; mitotic spindle assembly checkpoint MAD1-MAD2 complex; mitotic spindle pole; nuclear envelope; nuclear pore nuclear basket; spindle
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Molecular Function:
identical protein binding; kinetochore binding; protein binding
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Biological Process:
attachment of mitotic spindle microtubules to kinetochore; cell division; mitotic spindle assembly checkpoint signaling; negative regulation of T cell proliferation; positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of metaphase plate congression; thymus development
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Disease: Mosaic Variegated Aneuploidy Syndrome 7 With Inflammation And Tumor Predisposition; Prostate Cancer
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Reference #:
Q9Y6D9
(UniProtKB)
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Alt. Names/Synonyms: hMAD1; HsMAD1; MAD1; MAD1 mitotic arrest deficient like 1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1-like protein 1; MAD1L1; MD1L1; mitotic arrest deficient 1 like 1; Mitotic arrest deficient 1-like protein 1; Mitotic checkpoint MAD1 protein homolog; Mitotic spindle assembly checkpoint protein MAD1; mitotic-arrest deficient 1, yeast, homolog-like 1; PIG9; Tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181
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Gene Symbols: MAD1L1
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Molecular weight:
83,067 Da
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Basal Isoelectric point:
5.72
Predict pI for various phosphorylation states
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