UFL1 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition. Belongs to the UFL1 family. Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Tumor suppressor
Chromosomal Location of Human Ortholog: 6q16.1
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; neuron projection; protein-containing complex
Molecular Function:  protein binding; UFM1 transferase activity
Biological Process:  negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein ubiquitination; positive regulation of cell proliferation; positive regulation of glial cell proliferation; protein K69-linked ufmylation; protein ufmylation; regulation of intracellular estrogen receptor signaling pathway; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of protein localization; response to endoplasmic reticulum stress; response to L-glutamate
Reference #:  O94874 (UniProtKB)
Alt. Names/Synonyms: E3 UFM1-protein ligase 1; hypothetical protein LOC23376; KIAA0776; NLBP; novel LZAP-binding protein; RP3-393D12.1; UFL1
Gene Symbols: UFL1
Molecular weight: 89,595 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below

UFL1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene