IQSEC1 Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. Belongs to the BRAG family. Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p25.2-p25.1
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nucleolus
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; lipid binding; protein binding
Biological Process:  positive regulation of adherens junction organization; positive regulation of GTPase activity; positive regulation of keratinocyte migration; regulation of ARF protein signal transduction
Disease: Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities
Reference #:  Q6DN90 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF-GEP100; ARFGEP100; BRAG2; brefeldin A-resistant ARF-GEF2; Brefeldin-resistant Arf-GEF 2 protein; epididymis secretory sperm binding protein; GEP100; IDDSSBA; IQ motif and Sec7 domain 1; IQ motif and Sec7 domain ArfGEF 1; IQ motif and SEC7 domain-containing protein 1; IQEC1; IQSEC1; KIAA0763
Gene Symbols: IQSEC1
Molecular weight: 108,314 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein