CSIG Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. Belongs to the universal ribosomal protein uL1 family. Highly divergent. Expressed at high intensities in the heart, skeletal muscle, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 16p13.13
Cellular Component:  nucleolus
Molecular Function:  mRNA 3'-UTR binding; mRNA 5'-UTR binding
Biological Process:  regulation of apoptotic process; regulation of cellular senescence; regulation of protein localization
Reference #:  O76021 (UniProtKB)
Alt. Names/Synonyms: CATX-11; CATX11; cellular senescence inhibited gene protein; Cellular senescence-inhibited gene protein; CSIG; DKFZP564M182; L12; MGC138433; MGC142259; PBK1; Protein PBK1; ribosomal L1 domain containing 1; Ribosomal L1 domain-containing protein 1; RL1D1; RSL1D1; UTP30
Gene Symbols: RSL1D1
Molecular weight: 54,973 Da
Basal Isoelectric point: 10.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB