GTF3C1 a general transcription factor required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component:  nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; transcription factor TFIIIC complex
Molecular Function:  protein binding
Biological Process:  5S class rRNA transcription by RNA polymerase III; rRNA transcription; transcription by RNA polymerase III; tRNA transcription; tRNA transcription by RNA polymerase III
Reference #:  Q12789 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A111; General transcription factor 3C polypeptide 1; general transcription factor IIIC, polypeptide 1 (alpha subunit); general transcription factor IIIC, polypeptide 1, alpha 220kDa; GTF3C1; TF3C-alpha; TF3C1; TFIIIC; TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; TFIIIC220; TFIIICalpha; Transcription factor IIIC 220 kDa subunit; Transcription factor IIIC subunit alpha
Gene Symbols: GTF3C1
Molecular weight: 238,875 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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