DRIM Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Belongs to the UTP20 family. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component:  90S preribosome; cytoplasm; nucleolus; nucleoplasm; plasma membrane; preribosome, small subunit precursor; small-subunit processome
Molecular Function:  protein binding
Biological Process:  endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell proliferation; rRNA processing
Reference #:  O75691 (UniProtKB)
Alt. Names/Synonyms: down regulated in metastasis; Down-regulated in metastasis protein; DRIM; NNP73; Novel nucleolar protein 73; Protein Key-1A6; Small subunit processome component 20 homolog; UTP20; UTP20, small subunit (SSU) processome component, homolog (yeast)
Gene Symbols: UTP20
Molecular weight: 318,385 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
Select Structure to View Below

DRIM

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene