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DRIM
Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Belongs to the UTP20 family. Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; Translation |
| Chromosomal Location of human Ortholog: 12q23.2 |
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Cellular Component:
90S preribosome; cytoplasm; nucleolus; nucleoplasm; plasma membrane; preribosome, small subunit precursor; small-subunit processome
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Molecular Function:
protein binding
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Biological Process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing
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Reference #:
O75691
(UniProtKB)
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Alt. Names/Synonyms: 1A6/DRIM; down regulated in metastasis; Down-regulated in metastasis protein; DRIM; NNP73; Novel nucleolar protein 73; Protein Key-1A6; Small subunit processome component 20 homolog; UTP20; UTP20 small subunit (SSU) processome component; UTP20 small subunit processome component; UTP20, small subunit (SSU) processome component, homolog; UTP20, small subunit (SSU) processome component, homolog (yeast)
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Gene Symbols: UTP20
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Molecular weight:
318,385 Da
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Basal Isoelectric point:
7.07
Predict pI for various phosphorylation states
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| Select Structure to View Below |
DRIM
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