MYCBP2 Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues. Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3. Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins. Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration. Required for the formation of major central nervous system axon tracts. Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK. Required for proper localization of retinogeniculate projections but not for eye-specific segregation. Regulates axon guidance in the olfactory system. Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2. Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown. Regulates the internalization of TRPV1 in peripheral sensory neurons. May mediate ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia. May function as a facilitator or regulator of transcriptional activation by MYC. Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1. Belongs to the RING-Cys relay (RCR) family. Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Highly expressed in peripheral and central neurons. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 13q22.3
Cellular Component:  axon; cytoplasm; intracellular membrane-bounded organelle; microtubule cytoskeleton; nucleus
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; protein homodimerization activity; Ran GTPase binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; circadian regulation of gene expression; negative regulation of protein catabolic process; neuromuscular process; positive regulation of protein ubiquitination; protein ubiquitination; regulation of axon guidance; regulation of cytoskeleton organization; regulation of protein localization
Reference #:  O75592 (UniProtKB)
Alt. Names/Synonyms: DKFZp686M08244; E3 ubiquitin-protein ligase MYCBP2; FLJ10106; FLJ13826; FLJ21597; FLJ21646; Highwire; KIAA0916; MYC binding protein 2; MYC binding protein 2, E3 ubiquitin protein ligase; Myc-binding protein 2; Myc-bp2; MYCB2; MYCBP2; PAM; Pam/highwire/rpm-1 protein; PAM/Highwire/RPM-1 protein 1; Phr; PHR1; Probable E3 ubiquitin-protein ligase MYCBP2; Protein associated with Myc; RING-type E3 ubiquitin transferase MYCBP2
Gene Symbols: MYCBP2
Molecular weight: 513,636 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
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MYCBP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene