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CACTIN
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. Belongs to the CACTIN family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; RNA splicing; Spliceosome |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
catalytic step 2 spliceosome; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; spliceosomal complex
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Molecular Function:
protein binding
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Biological Process:
cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; innate immune response; mRNA cis splicing, via spliceosome; mRNA splicing, via spliceosome; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of innate immune response; negative regulation of interferon-beta production; negative regulation of interleukin-8 production; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein phosphorylation; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; negative regulation of type I interferon-mediated signaling pathway
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Reference #:
Q8WUQ7
(UniProtKB)
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Alt. Names/Synonyms: C19orf29; Cactin; cactin homolog; cactin, spliceosome C complex subunit; CATIN; chromosome 19 open reading frame 29; FLJ17482; FLJ59622; fSAPc; functional spliceosome-associated protein c; NY REN 24 antigen; NY-REN-24; NY-REN-24 antigen; Renal carcinoma antigen NY-REN-24; Splicing factor Cactin
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Gene Symbols: CACTIN
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Molecular weight:
88,702 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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