OGA Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. Belongs to the glycosyl hydrolase 84 family. Ubiquitous. Shows highest expression in the brain, placenta and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; EC; Hydrolase
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component:  cytosol; nucleus
Molecular Function:  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity; beta-N-acetylglucosaminidase activity; hyalurononglucosaminidase activity
Biological Process:  glycoprotein catabolic process; N-acetylglucosamine metabolic process; protein deglycosylation; protein O-linked glycosylation; viral process
Reference #:  O60502 (UniProtKB)
Alt. Names/Synonyms: Beta-hexosaminidase; Beta-N-acetylhexosaminidase; Bifunctional protein NCOAT; FLJ11229; FLJ23355; HAT; HEXC; Hexosaminidase C; Histone acetyltransferase; hyaluronidase in meningioma; KIAA0679; MEA5; meningioma expressed antigen 5 (hyaluronidase); Meningioma-expressed antigen 5; MGEA5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; NCOAT; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; O-GlcNAcase; OGA; Protein O-GlcNAcase
Gene Symbols: OGA
Molecular weight: 102,915 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein