| OGA Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. Belongs to the glycosyl hydrolase 84 family. Ubiquitous. Shows highest expression in the brain, placenta and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Acetyltransferase; EC 3.2.1.169; Hydrolase |
| Chromosomal Location of human Ortholog: 10q24.32 |
| Cellular Component: cytosol; nucleus |
| Molecular Function: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity; beta-N-acetylglucosaminidase activity; hyalurononglucosaminidase activity; identical protein binding |
| Biological Process: glycoprotein catabolic process; glycoprotein metabolic process; N-acetylglucosamine metabolic process; protein deglycosylation; protein O-linked glycosylation |
| Reference #: O60502 (UniProtKB) |
| Alt. Names/Synonyms: Beta-hexosaminidase; Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidase; Bifunctional protein NCOAT; FLJ11229; FLJ23355; HAT; HEXC; Hexosaminidase C; Histone acetyltransferase; hyaluronidase in meningioma; KIAA0679; MEA5; meningioma expressed antigen 5 (hyaluronidase); Meningioma-expressed antigen 5; MGEA5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; NCOAT; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; O-GlcNAcase; OGA; Protein O-GlcNAcase |
| Gene Symbols: OGA |
| Molecular weight: 102,915 Da |
| Basal Isoelectric point: 4.82 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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OGA |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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