TNRC15 iso3 Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. Belongs to the GIGYF family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  cytoplasmic stress granule; cytosol; endoplasmic reticulum; endosome; Golgi apparatus; membrane; perikaryon; protein-containing complex; proximal dendrite; vesicle
Molecular Function:  molecular adaptor activity; proline-rich region binding; protein binding
Biological Process:  adult locomotory behavior; feeding behavior; homeostasis of number of cells within a tissue; insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; mRNA destabilization; multicellular organism growth; musculoskeletal movement; negative regulation of translation; negative regulation of translational initiation; negative regulation of type I interferon-mediated signaling pathway; neuromuscular process controlling balance; post-embryonic development; post-transcriptional gene silencing; rescue of stalled ribosome; spinal cord motor neuron differentiation
Disease: Parkinson Disease 11, Autosomal Dominant
Reference #:  Q6Y7W6-3 (UniProtKB)
Alt. Names/Synonyms: DKFZp686I15154; DKFZp686J17223; FLJ23368; GGYF2; GIGYF2; GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 2; GYF domain containing 2; GYF2; KIAA0642; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 2; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; TNRC15 iso3; trinucleotide repeat containing 15; Trinucleotide repeat-containing gene 15 protein
Gene Symbols: GIGYF2
Molecular weight: 152,399 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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TNRC15 iso3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein