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TNRC15 iso3
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. Belongs to the GIGYF family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation |
| Chromosomal Location of human Ortholog: 2q37.1 |
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Cellular Component:
cytoplasmic stress granule; cytosol; endoplasmic reticulum; endosome; Golgi apparatus; membrane; perikaryon; protein-containing complex; proximal dendrite; vesicle
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Molecular Function:
proline-rich region binding; protein binding
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Biological Process:
adult locomotory behavior; feeding behavior; homeostasis of number of cells within a tissue; insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; mRNA destabilization; multicellular organism growth; musculoskeletal movement; negative regulation of translation; neuromuscular process controlling balance; post-embryonic development; post-transcriptional gene silencing; protein metabolic process; spinal cord motor neuron differentiation
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Disease: Parkinson Disease 11, Autosomal Dominant
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Reference #:
Q6Y7W6-3
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686I15154; DKFZp686J17223; FLJ23368; GGYF2; GIGYF2; GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 2; GYF domain containing 2; GYF2; KIAA0642; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 2; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; TNRC15 iso3; trinucleotide repeat containing 15; Trinucleotide repeat-containing gene 15 protein
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Gene Symbols: GIGYF2
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Molecular weight:
152,399 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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