CDP138 Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 12p12.1
Cellular Component:  cell cortex; cytoplasmic vesicle membrane; cytosol; microtubule organizing center; plasma membrane; ruffle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding
Biological Process:  cellular response to insulin stimulus; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; intracellular protein transmembrane transport; positive regulation of glucose import; positive regulation of glucose transmembrane transport; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; vesicle fusion
Reference #:  Q86YS7 (UniProtKB)
Alt. Names/Synonyms: 138 kDa C2 domain-containing phosphoprotein; C2 calcium dependent domain containing 5; C2 calcium-dependent domain containing 5; C2 domain-containing phosphoprotein of 138 kDa; C2 domain-containing protein 5; C2CD5; CDP138; KIAA0528
Gene Symbols: C2CD5
Molecular weight: 110,447 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene