TAT-SF1 Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. Belongs to the HTATSF1 family. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Spliceosome; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq26.3
Cellular Component:  nucleoplasm; nucleus
Biological Process:  mRNA splicing, via spliceosome; regulation of DNA-templated transcription, elongation; regulation of transcription by RNA polymerase II; viral genome replication
Reference #:  O43719 (UniProtKB)
Alt. Names/Synonyms: cofactor required for Tat activation of HIV-1 transcription; dJ196E23.2; HIV TAT specific factor 1; HIV Tat-specific factor 1; HIV-1 Tat specific factor 1; HTATSF1; HTSF1; Tat-SF1; TATSF1
Gene Symbols: HTATSF1
Molecular weight: 85,853 Da
Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states
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TAT-SF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein