SART1 Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Belongs to the SNU66/SART1 family. Ubiquitously expressed. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  Cajal body; catalytic step 2 spliceosome; cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus; U2-type precatalytic spliceosome
Molecular Function:  protein binding
Biological Process:  mRNA splicing, via spliceosome; positive regulation of cytotoxic T cell differentiation; spliceosomal snRNP assembly
Reference #:  O43290 (UniProtKB)
Alt. Names/Synonyms: Ara1; HAF; HOMS1; hSART-1; hSnu66; hypoxia associated factor; IgE autoantigen; MGC2038; SART-1; SART1; SART1(259) protein; SART1(800) protein; SART1, U4/U6.U5 tri-snRNP-associated protein 1; SART1259; small nuclear ribonucleoprotein 110kDa (U4/U6.U5); SNRNP110; Snu66; SNU66 homolog; SNUT1; spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP; squamous cell carcinoma antigen recognised by T cells; squamous cell carcinoma antigen recognized by T cells; Squamous cell carcinoma antigen recognized by T cells 1; Squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; U4/U6.U5 tri-snRNP-associated protein 1
Gene Symbols: SART1
Molecular weight: 90,255 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below

SART1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene