SIPA1L1 Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 14q24.2
Cellular Component:  cell junction; cytoplasm; cytoskeleton; dendritic spine; postsynaptic density; postsynaptic membrane
Molecular Function:  ephrin receptor binding; GTPase activator activity
Biological Process:  actin cytoskeleton reorganization; activation of GTPase activity; ephrin receptor signaling pathway; regulation of axonogenesis; regulation of dendritic spine morphogenesis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; regulation of synaptic plasticity
Reference #:  O43166 (UniProtKB)
Alt. Names/Synonyms: DKFZp686G1344; E6-targeted protein 1; E6TP1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; KIAA0440; SI1L1; signal-induced proliferation-associated 1 like 1; signal-induced proliferation-associated 1-like 1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SIPA1L1; WUGSC:H_DJ1140G11.1
Gene Symbols: SIPA1L1
Molecular weight: 200,028 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB