|
ECM29
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis. Promotes proteasome dissociation under oxidative stress. Belongs to the ECM29 family. Note: This description may include information from UniProtKB.
|
| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: 9q31.3 |
|
Cellular Component:
centrosome; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytoplasmic vesicle; early endosome; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; late endosome; multivesicular body; nucleoplasm; nucleus; proteasome complex; trans-Golgi network
|
|
Molecular Function:
molecular adaptor activity; proteasome binding; protein binding
|
|
Biological Process:
proteasome assembly; ubiquitin-dependent ERAD pathway
|
|
Reference #:
Q5VYK3
(UniProtKB)
|
|
Alt. Names/Synonyms: ECM29; ECM29 homolog, proteasome accessory protein; Ecm29 proteasome adapter and scaffold; Ecm29 proteasome adaptor and scaffold; ECPAS; FLJ22036; homolog of yeast Ecm29; KIAA0368; KIAA1962; Proteasome adapter and scaffold protein ECM29; Proteasome-associated protein ECM29 homolog; RP11-386D8.2
|
|
Gene Symbols: ECPAS
|
|
Molecular weight:
204,291 Da
|
|
Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
|
