ECM29 Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis. Promotes proteasome dissociation under oxidative stress. Belongs to the ECM29 family. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 9q31.3
Cellular Component:  centrosome; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytoplasmic vesicle; early endosome; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; late endosome; multivesicular body; nucleoplasm; nucleus; proteasome complex; trans-Golgi network
Molecular Function:  molecular adaptor activity; proteasome binding; protein binding
Biological Process:  proteasome assembly; ubiquitin-dependent ERAD pathway
Reference #:  Q5VYK3 (UniProtKB)
Alt. Names/Synonyms: ECM29; ECM29 homolog, proteasome accessory protein; Ecm29 proteasome adapter and scaffold; Ecm29 proteasome adaptor and scaffold; ECPAS; FLJ22036; homolog of yeast Ecm29; KIAA0368; KIAA1962; Proteasome adapter and scaffold protein ECM29; Proteasome-associated protein ECM29 homolog; RP11-386D8.2
Gene Symbols: ECPAS
Molecular weight: 204,291 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene