SETD1A
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Belongs to the class V-like SAM-binding methyltransferase superfamily. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine |
Chromosomal Location of human Ortholog: 16p11.2 |
Cellular Component:
chromatin; histone methyltransferase complex; nuclear speck; nucleoplasm; nucleus; Set1C/COMPASS complex
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Molecular Function:
beta-catenin binding; histone H3K4 methyltransferase activity; histone H3K4 monomethyltransferase activity; histone H3K4 trimethyltransferase activity; protein binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding
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Biological Process:
brain development; chromatin remodeling; DNA damage response; histone H3-K4 methylation; regulation of chromatin organization; regulation of hematopoietic stem cell differentiation
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Disease: Epilepsy, Early-onset, With Or Without Developmental Delay; Neurodevelopmental Disorder With Speech Impairment And Dysmorphic Facies
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Reference #:
O15047
(UniProtKB)
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Alt. Names/Synonyms: EPEDD; Histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain containing 1A, histone lysine methyltransferase; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SETD1A
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Gene Symbols: SETD1A
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Molecular weight:
186,034 Da
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Basal Isoelectric point:
5.07
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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