hnRNP D-like Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 4q21.22
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  protein binding
Biological Process:  interleukin-12-mediated signaling pathway
Disease: Limb-girdle Muscular Dystrophy, Type 1g
Reference #:  O14979 (UniProtKB)
Alt. Names/Synonyms: A+U-rich element RNA binding factor; AU-rich element RNA-binding factor; Heterogeneous nuclear ribonucleoprotein D-like; HNRDL; hnRNP D-like; hnRNP DL; HNRPDL; JKT41-binding protein; JKTBP; JKTBP2; laAUF1; Protein laAUF1
Gene Symbols: HNRNPDL
Molecular weight: 46,438 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
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hnRNP D-like

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein