hnRNP D-like Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 4q21.22
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  protein binding
Biological Process:  interleukin-12-mediated signaling pathway
Disease: Limb-girdle Muscular Dystrophy, Type 1g
Reference #:  O14979 (UniProtKB)
Alt. Names/Synonyms: A+U-rich element RNA binding factor; AU-rich element RNA-binding factor; Heterogeneous nuclear ribonucleoprotein D-like; HNRDL; hnRNP D-like; hnRNP DL; HNRPDL; JKT41-binding protein; JKTBP; JKTBP2; laAUF1; Protein laAUF1
Gene Symbols: HNRNPDL
Molecular weight: 46,438 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
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hnRNP D-like

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein