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ASCL1
a transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 12q23.2 |
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Cellular Component:
chromatin; neuronal cell body; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
bHLH transcription factor binding; chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; identical protein binding; nucleic acid binding; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
adrenal chromaffin cell differentiation; carotid body glomus cell differentiation; cell maturation; cellular response to magnetism; central nervous system neuron development; cerebral cortex development; cerebral cortex GABAergic interneuron differentiation; commitment of neuronal cell to specific neuron type in forebrain; heart development; lung epithelial cell differentiation; lung neuroendocrine cell differentiation; motor neuron migration; musculoskeletal movement, spinal reflex action; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuroblast fate determination; neuroblast proliferation; neurogenesis; neuron development; neuron differentiation; neuron fate commitment; neuron fate specification; noradrenergic neuron development; noradrenergic neuron fate commitment; Notch signaling pathway; olfactory pit development; oligodendrocyte development; peripheral nervous system neuron development; positive regulation of cell cycle; positive regulation of neural precursor cell proliferation; positive regulation of neurogenesis; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of epithelial cell differentiation; regulation of gene expression; regulation of mitotic cell cycle; regulation of neurogenesis; regulation of timing of subpallium neuron differentiation; response to epidermal growth factor; response to folic acid; response to retinoic acid; sensory organ development; spinal cord association neuron differentiation; spinal cord oligodendrocyte cell fate specification; stomach neuroendocrine cell differentiation; subpallium neuron fate commitment; sympathetic ganglion development; sympathetic nervous system development; ventral spinal cord interneuron fate commitment; vestibular nucleus development
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Disease: Central Hypoventilation Syndrome, Congenital
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Reference #:
P50553
(UniProtKB)
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Alt. Names/Synonyms: achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex homolog 1 (Drosophila); achaete-scute complex-like 1; achaete-scute family bHLH transcription factor 1; Achaete-scute homolog 1; ASCL1; ASH-1; ASH1; BHLHA46; Class A basic helix-loop-helix protein 46; HASH1; MASH1
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Gene Symbols: ASCL1
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Molecular weight:
25,454 Da
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Basal Isoelectric point:
8.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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