ASCL1 a transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  neuronal cell body; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  bHLH transcription factor binding; chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; protein binding; protein dimerization activity; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  adrenal chromaffin cell differentiation; carotid body glomus cell differentiation; cell differentiation; cell maturation; central nervous system neuron development; cerebral cortex development; commitment of neuronal cell to specific neuron type in forebrain; enteric nervous system development; forebrain neuron differentiation; generation of neurons; glial cell differentiation; lung neuroendocrine cell differentiation; multicellular organism development; musculoskeletal movement, spinal reflex action; negative regulation of apoptotic process; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nervous system development; neuroblast fate determination; neuroblast proliferation; neurogenesis; neuron development; neuron differentiation; neuron fate commitment; neuron fate specification; neuron migration; noradrenergic neuron development; noradrenergic neuron fate commitment; Notch signaling pathway; olfactory pit development; oligodendrocyte cell fate commitment; oligodendrocyte development; oligodendrocyte differentiation; parasympathetic nervous system development; pattern specification process; positive regulation of cell cycle; positive regulation of neural precursor cell proliferation; positive regulation of neurogenesis; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of cell proliferation; regulation of epithelial cell differentiation; regulation of gene expression; regulation of mitotic cell cycle; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of timing of subpallium neuron differentiation; regulation of transcription by RNA polymerase II; sensory organ development; spinal cord association neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; stomach neuroendocrine cell differentiation; subpallium neuron fate commitment; sympathetic ganglion development; sympathetic nervous system development; ventral spinal cord interneuron fate commitment; vestibular nucleus development
Reference #:  Q02067 (UniProtKB)
Alt. Names/Synonyms: achaete-scute complex homolog 1 (Drosophila); achaete-scute complex homolog-like 1; achaete-scute complex-like protein 1; achaete-scute family bHLH transcription factor 1; Achaete-scute homolog 1; AI225900; Ascl1; ASH-1; Ash1; bHLHa; bHLHa46; mammalian achaete scute homolog 1; Mas; Mash-1; Mash1; OTTMUSP00000029198
Gene Symbols: Ascl1
Molecular weight: 24,741 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Select Structure to View Below

ASCL1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene