AKAP13 Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3. Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy. Has no guanine nucleotide exchange activity on CDC42, Ras or Rac. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes. Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol. Required for normal adaptive cardiac hypertrophy in response to pressure overload. Plays a role in osteogenesis. Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 7|7 D1
Cellular Component:  cell cortex; cytoplasm; cytoskeleton; cytosol; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function:  cAMP-dependent protein kinase activity; guanyl-nucleotide exchange factor activity; MAP-kinase scaffold activity; metal ion binding; molecular adaptor activity; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; adrenergic receptor signaling pathway; bone development; cardiac muscle cell differentiation; cell growth involved in cardiac muscle cell development; G protein-coupled receptor signaling pathway; heart development; intracellular signal transduction; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAP kinase activity; positive regulation of Rho protein signal transduction; regulation of glucocorticoid mediated signaling pathway; regulation of Rho protein signal transduction; regulation of sarcomere organization
Reference #:  E9Q394 (UniProtKB)
Alt. Names/Synonyms: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; AKAP; AKAP-13; AKAP-Lbc; Akap13; AKP13; BRX; Ht31; LBC; PRO; PROT; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31
Gene Symbols: Akap13
Molecular weight: 303,976 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA