AKAP13 Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 7|7 D1
Cellular Component:  cell cortex; cytoplasm; cytoskeleton; cytosol; membrane; nucleus; perinuclear region of cytoplasm
Molecular Function:  cAMP-dependent protein kinase activity; guanyl-nucleotide exchange factor activity; MAP-kinase scaffold activity; metal ion binding; molecular adaptor activity; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; adrenergic receptor signaling pathway; bone development; cardiac muscle cell differentiation; cell growth involved in cardiac muscle cell development; G protein-coupled receptor signaling pathway; heart development; intracellular signal transduction; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAP kinase activity; positive regulation of Rho protein signal transduction; regulation of glucocorticoid mediated signaling pathway; regulation of Rho protein signal transduction; regulation of sarcomere organization
Reference #:  E9Q394 (UniProtKB)
Alt. Names/Synonyms: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; AKAP-Lbc; Akap13; AKP13; BRX; Ht31; LBC; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31
Gene Symbols: Akap13
Molecular weight: 303,976 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA