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CDK16
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Detected in pancreas islets (at protein level). Detected in brain and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CDK family; CDK/PCTAIRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; PCTAIRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: X A1.3|X 16.18 cM |
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Cellular Component:
cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; microtubule cytoskeleton; neuron projection; nucleus; plasma membrane; synapse; synaptic vesicle
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Molecular Function:
ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell differentiation; exocytosis; growth hormone secretion; neuron projection development; phosphorylation; positive regulation of autophagy; protein phosphorylation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription involved in G1/S transition of mitotic cell cycle; spermatogenesis
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Reference #:
Q04735
(UniProtKB)
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Alt. Names/Synonyms: Cdk16; Cell division protein kinase 16; Crk; CRK5; Cyclin-dependent kinase 16; OTTMUSP00000018660; Pcta; PCTAIRE-motif protein kinase 1; Pctaire1; Pctk; Pctk1; Serine/threonine-protein kinase PCTAIRE-1
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Gene Symbols: Cdk16
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Molecular weight:
55,914 Da
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Basal Isoelectric point:
7.71
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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