CDK16 Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Detected in pancreas islets (at protein level). Detected in brain and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/TAIRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); TAIRE subfamily
Chromosomal Location of Human Ortholog: X A1.3|X 16.18 cM
Cellular Component:  cell junction; cytoplasm; cytoplasmic vesicle; cytosol; extrinsic component of cytoplasmic side of plasma membrane; microtubule cytoskeleton; neuron projection; nucleus; plasma membrane; synapse; synaptic vesicle
Molecular Function:  ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell differentiation; exocytosis; growth hormone secretion; neuron projection development; phosphorylation; protein phosphorylation; regulation of insulin secretion involved in cellular response to glucose stimulus; spermatogenesis
Reference #:  Q04735 (UniProtKB)
Alt. Names/Synonyms: Cdk16; Cell division protein kinase 16; CRK5; Cyclin-dependent kinase 16; OTTMUSP00000018660; PCTAIRE-motif protein kinase 1; Pctaire1; Pctk1; Serine/threonine-protein kinase PCTAIRE-1
Gene Symbols: Cdk16
Molecular weight: 55,914 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK16

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene