NEDD4L E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 18|18 E1
Cellular Component:  cytoplasm; endosome; Golgi apparatus
Molecular Function:  ion channel binding; potassium channel inhibitor activity; potassium channel regulator activity; protein binding; sodium channel inhibitor activity; sodium channel regulator activity; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  cell differentiation; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein localization to cell surface; negative regulation of sodium ion transmembrane transport; negative regulation of sodium ion transmembrane transporter activity; negative regulation of sodium ion transport; negative regulation of systemic arterial blood pressure; positive regulation of cation channel activity; positive regulation of caveolin-mediated endocytosis; positive regulation of dendrite extension; positive regulation of protein catabolic process; positive regulation of sodium ion transport; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein monoubiquitination; protein polyubiquitination; protein ubiquitination; regulation of bicellular tight junction assembly; regulation of dendrite morphogenesis; regulation of ion transmembrane transport; regulation of membrane depolarization; regulation of membrane potential; regulation of membrane repolarization; regulation of potassium ion transmembrane transporter activity; regulation of protein stability; response to metal ion; response to salt stress; ubiquitin-dependent protein catabolic process; ventricular cardiac muscle cell action potential
Reference #:  Q8CFI0 (UniProtKB)
Alt. Names/Synonyms: 1300012C07Rik; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; Kiaa0439; NED4L; Nedd4; Nedd4-; Nedd4-2; NEDD4.2; Nedd4b; Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like; neural precursor cell expressed, developmentally down-regulated gene 4b
Gene Symbols: Nedd4l
Molecular weight: 115,419 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NEDD4L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene