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NSF
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle |
| Chromosomal Location of mouse Ortholog: 11 E1|11 67.54 cM |
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Cellular Component:
cytoplasm; cytosol; dendritic shaft; Golgi apparatus; Golgi stack; plasma membrane
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent protein binding; D1 dopamine receptor binding; hydrolase activity; ionotropic glutamate receptor binding; metal ion binding; nucleotide binding; PDZ domain binding; protein binding; protein kinase binding; protein serine/threonine kinase binding; protein-containing complex binding; small GTPase binding; syntaxin binding; syntaxin-1 binding
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Biological Process:
Golgi to plasma membrane protein transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process; positive regulation of receptor recycling; positive regulation of receptor-mediated endocytosis; potassium ion transport; protein transport; protein-containing complex disassembly; regulation of exocytosis; regulation of receptor internalization; SNARE complex disassembly; vesicle-mediated transport
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Reference #:
P46460
(UniProtKB)
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Alt. Names/Synonyms: AI316878; AU020090; AU067812; N-ethylmaleimide sensitive factor; N-ethylmaleimide sensitive fusion protein; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Nsf; OTTMUSP00000002926; Protein SKD2; SKD; Skd2; Suppressor of K(+) transport growth defect 2; Vesicle-fusing ATPase; Vesicular-fusion protein NSF
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Gene Symbols: Nsf
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Molecular weight:
82,613 Da
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Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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