Kv7.3 iso2 Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  axon initial segment; cell surface; dendrite; integral component of membrane; integral component of plasma membrane; membrane raft; neuron projection; neuronal cell body; node of Ranvier; plasma membrane; somatodendritic compartment; voltage-gated potassium channel complex
Molecular Function:  calmodulin binding; delayed rectifier potassium channel activity; ion channel binding; potassium channel activity; protein kinase binding; ubiquitin protein ligase binding; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  cellular response to ammonium ion; ganglion development; ion transmembrane transport; membrane hyperpolarization; oligodendrocyte development; potassium ion transmembrane transport; regulation of ion transmembrane transport
Reference #:  O88944-2 (UniProtKB)
Alt. Names/Synonyms: Kcnq3; KQT-like 3; Potassium channel subunit alpha KvLQT3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; Voltage-gated potassium channel subunit Kv7.3
Gene Symbols: Kcnq3
Molecular weight: 93,601 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below

Kv7.3 iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene