ASBT Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of human Ortholog: 13q33.1
Cellular Component:  apical plasma membrane; microvillus; plasma membrane
Molecular Function:  bile acid:sodium symporter activity; protein binding
Biological Process:  bile acid and bile salt transport; response to bacterium; sodium ion transport; transmembrane transport
Disease: Bile Acid Malabsorption, Primary
Reference #:  Q12908 (UniProtKB)
Alt. Names/Synonyms: Apical sodium-dependent bile acid transporter; ASBT; IBAT; ileal apical sodium-dependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na(+)-dependent ileal bile acid transporter; NTCP2; PBAM; SLC10A2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; solute carrier family 10 (sodium/bile acid cotransporter), member 2; Solute carrier family 10 member 2
Gene Symbols: SLC10A2
Molecular weight: 37,714 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein