|
ASBT
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter |
| Chromosomal Location of rat Ortholog: 16q12.5 |
|
Cellular Component:
apical plasma membrane; microvillus; proteasome complex
|
|
Molecular Function:
bile acid:sodium symporter activity
|
|
Biological Process:
bile acid and bile salt transport; bile acid metabolic process; response to bacterium; sodium ion transport; transmembrane transport
|
|
Reference #:
Q62633
(UniProtKB)
|
|
Alt. Names/Synonyms: Apical sodium-dependent bile acid transporter; ASBT; IBAT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Ntcp2; Slc10a2; Sodium/taurocholate-cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Solute carrier family 10 member 2; solute carrier family 10, member 2
|
|
Gene Symbols: Slc10a2
|
|
Molecular weight:
38,024 Da
|
|
Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
|
