vinexin iso2 Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component:  cytoskeleton; cytosol; nucleus
Molecular Function:  protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin binding
Biological Process:  actin filament organization; cell adhesion; cell-substrate adhesion; muscle contraction; negative regulation of transcription by RNA polymerase II; positive regulation of cytoskeleton organization; positive regulation of MAPK cascade; positive regulation of stress fiber assembly
Reference #:  O60504-2 (UniProtKB)
Alt. Names/Synonyms: SCAM-1; SCAM1; SH3-containing adapter molecule 1; SH3D4; sorbin and SH3 domain containing 3; Sorbin and SH3 domain-containing protein 3; SORBS3; VINEX; Vinexin; vinexin beta (SH3-containing adaptor molecule-1)
Gene Symbols: SORBS3
Molecular weight: 36,742 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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vinexin iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein