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vinexin iso2
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 8p21.3 |
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Cellular Component:
cell-substrate junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleus
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Molecular Function:
protein binding; structural constituent of cytoskeleton; vinculin binding
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Biological Process:
cell adhesion; cell-substrate adhesion; cytoskeleton organization; MAPK cascade; negative regulation of transcription by RNA polymerase II; positive regulation of cytoskeleton organization; positive regulation of MAPK cascade; positive regulation of stress fiber assembly
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Reference #:
O60504-2
(UniProtKB)
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Alt. Names/Synonyms: SCAM-1; SCAM1; SH3-containing adapter molecule 1; SH3D4; sorbin and SH3 domain containing 3; Sorbin and SH3 domain-containing protein 3; SORBS3; VINEX; Vinexin; vinexin beta (SH3-containing adaptor molecule-1); vinexin iso2
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Gene Symbols: SORBS3
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Molecular weight:
36,742 Da
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Basal Isoelectric point:
8.86
Predict pI for various phosphorylation states
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