NEDD4L E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 18q21.31
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; multivesicular body; nucleoplasm; plasma membrane
Molecular Function:  potassium channel inhibitor activity; potassium channel regulator activity; protein binding; sodium channel inhibitor activity; sodium channel regulator activity; transmembrane transporter binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  cell differentiation; monoatomic ion transmembrane transport; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein localization to cell surface; negative regulation of sodium ion transmembrane transport; negative regulation of sodium ion transmembrane transporter activity; positive regulation of caveolin-mediated endocytosis; positive regulation of dendrite extension; positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein monoubiquitination; protein ubiquitination; regulation of dendrite morphogenesis; regulation of membrane depolarization; regulation of membrane potential; regulation of membrane repolarization; regulation of monoatomic ion transmembrane transport; regulation of potassium ion transmembrane transporter activity; regulation of protein stability; regulation of sodium ion transmembrane transport; ubiquitin-dependent protein catabolic process; ventricular cardiac muscle cell action potential
Disease: Periventricular Nodular Heterotopia 7
Reference #:  Q96PU5 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; hNedd4-2; KIAA0439; NED4L; NEDD4 like E3 ubiquitin protein ligase; Nedd4-2; NEDD4.2; NEDD4L; NEDL3; neural precursor cell expressed, developmentally down-regulated 4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4-like; PVNH7; RSP5; ubiquitin-protein ligase NEDD4-like; ubiquitin-protein ligase Rsp5
Gene Symbols: NEDD4L
Molecular weight: 111,932 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NEDD4L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein