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PLCL1
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Phospholipase |
| Chromosomal Location of mouse Ortholog: 1|1 C1.2 |
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Cellular Component:
cytoplasm
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Molecular Function:
GABA receptor binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
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Biological Process:
gamma-aminobutyric acid signaling pathway; intracellular signal transduction; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of synaptic transmission, GABAergic; signal transduction
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Reference #:
Q3USB7
(UniProtKB)
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Alt. Names/Synonyms: C230017K02Rik; Inactive phospholipase C-like protein 1; KIAA1092; phospholipase C, eta 2 pseudogene; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L; PLC-L1; PLCE; PLCL; Plcl1; PLDL1; PRIP; PRIP-1
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Gene Symbols: Plcl1
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Molecular weight:
122,673 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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