PLCL1 Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Phospholipase
Chromosomal Location of Human Ortholog: 1|1 C1.2
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  GABA receptor binding; inositol 1,4,5 trisphosphate binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
Biological Process:  gamma-aminobutyric acid signaling pathway; inositol trisphosphate biosynthetic process; intracellular signal transduction; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of peptidyl-serine phosphorylation; regulation of synaptic transmission, GABAergic; signal transduction
Reference #:  Q3USB7 (UniProtKB)
Alt. Names/Synonyms: C230017K02Rik; Inactive phospholipase C-like protein 1; KIAA1092; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L; PLC-L1; PLCE; PLCL; Plcl1; PLDL1; PRIP; PRIP-1
Gene Symbols: Plcl1
Molecular weight: 122,673 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein