|
PLCL1
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Phospholipase |
| Chromosomal Location of Human Ortholog: 1|1 C1.2 |
|
Cellular Component:
cytoplasm; plasma membrane
|
|
Molecular Function:
GABA receptor binding; inositol 1,4,5 trisphosphate binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
|
|
Biological Process:
gamma-aminobutyric acid signaling pathway; inositol trisphosphate biosynthetic process; intracellular signal transduction; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of peptidyl-serine phosphorylation; regulation of synaptic transmission, GABAergic; signal transduction
|
|
Reference #:
Q3USB7
(UniProtKB)
|
|
Alt. Names/Synonyms: C230017K02Rik; Inactive phospholipase C-like protein 1; KIAA1092; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L; PLC-L1; PLCE; PLCL; Plcl1; PLDL1; PRIP; PRIP-1
|
|
Gene Symbols: Plcl1
|
|
Molecular weight:
122,673 Da
|
|
Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
