IRS2 May mediate the control of various cellular processes by insulin. Interacts with PHIP. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8 A1.1|8 5.35 cM
Cellular Component:  cytoplasm; cytosol; plasma membrane; protein-containing complex
Molecular Function:  14-3-3 protein binding; insulin receptor binding; phosphatidylinositol 3-kinase binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding
Biological Process:  brain development; cell proliferation; cellular response to insulin stimulus; insulin receptor signaling pathway; mammary gland development; negative regulation of B cell apoptotic process; negative regulation of kinase activity; negative regulation of plasma membrane long-chain fatty acid transport; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; positive regulation of mesenchymal cell proliferation; response to glucose; signal transduction
Reference #:  P81122 (UniProtKB)
Alt. Names/Synonyms: 4PS; Insulin receptor substrate 2; IRS-2; Irs2
Gene Symbols: Irs2
Molecular weight: 136,763 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRS2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene