NRK1 Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. Belongs to the uridine kinase family. NRK subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.1.173; EC 2.7.1.22; Kinase, other
Chromosomal Location of human Ortholog: 9q21.13
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; metal ion binding; protein binding; ribosylnicotinamide kinase activity; ribosylnicotinate kinase activity
Biological Process:  NAD biosynthetic process; NAD metabolic process; phosphorylation
Reference #:  Q9NWW6 (UniProtKB)
Alt. Names/Synonyms: bA235O14.2; C9orf95; chromosome 9 open reading frame 95; FLJ20559; Nicotinamide riboside kinase 1; Nicotinic acid riboside kinase 1; NmR-K 1; NMRK1; NRK 1; NRK1; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1; RNK 1; RP11-235O14.2
Gene Symbols: NMRK1
Molecular weight: 23,193 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Select Structure to View Below

NRK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene