FMIP Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. Belongs to the THOC5 family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; RNA splicing; Spliceosome
Chromosomal Location of human Ortholog: 22q12.2
Cellular Component:  chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus; THO complex; THO complex part of transcription export complex; transcription export complex
Molecular Function:  mRNA binding; protein binding
Biological Process:  monocyte differentiation; mRNA export from nucleus; mRNA processing; negative regulation of DNA damage checkpoint; positive regulation of DNA-templated transcription, elongation; primitive hemopoiesis; RNA splicing; viral mRNA export from host cell nucleus
Reference #:  Q13769 (UniProtKB)
Alt. Names/Synonyms: C22orf19; Fmip; Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; PP39.2; THO complex 5; THO complex subunit 5 homolog; THOC5
Gene Symbols: THOC5
Molecular weight: 78,508 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein