PPM1D Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. Belongs to the PP2C family. Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  metal ion binding; mitogen-activated protein kinase binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity
Biological Process:  cellular response to starvation; chromatin silencing; DNA damage response, signal transduction by p53 class mediator; DNA methylation; G2/M transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of gene expression, epigenetic; peptidyl-threonine dephosphorylation; protein dephosphorylation; protein phosphorylation; response to bacterium; response to radiation; transcription initiation from RNA polymerase II promoter
Disease: Breast Cancer; Intellectual Developmental Disorder With Gastrointestinal Difficulties And High Pain Threshold
Reference #:  O15297 (UniProtKB)
Alt. Names/Synonyms: IDDGIP; JDVS; p53-induced protein phosphatase 1; PP2C-delta; PPM1D; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; protein phosphatase, Mg2+/Mn2+ dependent 1D; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; WIP1
Gene Symbols: PPM1D
Molecular weight: 66,675 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA